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Collagen X is a homotrimeric
2019-08-27
Collagen X is a homotrimeric molecule of three α1(X) chains (Mr 59 kDa) comprising a 45 kDa triple-helical domain flanked by an N-terminal (NC2) and a larger C-terminal (NC1) non-collagenous domains (Shen, 2005). In the hypertrophic ECM, collagen X most likely forms an extended hexagonal network, as
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palmitic acid In recent years the use of
2019-08-27
In recent years, the use of liquid chromatography/tandem mass spectrometry (LC–MS/MS) has become a preferred approach to measure drugs and metabolites in biological fluids due to its very high selectivity and sensitivity [17], [18], [19], [20], [21], [22], [23], [25], [30]. The great sensitivity of
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Recently it was reported that Crm is linked to spindle
2019-08-27
Recently, it was reported that Crm1 is linked to spindle pole body (SPB) by Spc72 in adenosine receptor antagonist yeast [9]. Spc72 and Spc110 are two specific receptors of γ-tubulin complex (Tub4), which target Tub4 to SPB and mediate the nucleation of microtubules from SPB [20]. It was found that
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In the present study we have examined an alternative approac
2019-08-27
In the present study, we have examined, an alternative approach for introduction of Hyp into bacterial, non-animal collagens. Previously, Gruskin and colleagues [27] had shown that Hyp could be introduced into recombinant mammalian collagen sequences in E. coli through a mechanism of co-translationa
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br Conflict of interest br Acknowledgements This work
2019-08-27
Conflict of interest Acknowledgements This work was supported in part by JSPS KAKENHI Grant Number 26292031. We thank Nissan Chemical Industries, Ltd. for the gift of the sample of fluralaner. Introduction As one of the most common cancers in southern China and southeast Asia, nasopharynge
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In silico modelling studies might aid our understanding of
2019-08-27
In silico modelling studies might aid our understanding of the functionality and potential biological activity of food and, in the long-term they might underpin the development of personalised diets to reduce health risks and help us to better understand pharmaceutical/food interactions. Acknowle
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br Materials and Methods br Results br
2019-08-27
Materials and Methods Results Discussion The spatial properties of receptor-ligand interactions can influence receptor activation and signal propagation, but studying this phenomenon requires the development of systems capable of recapitulating complex biophysical traits. In this study, we
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OxLDL down regulates eNOS and up
2019-08-27
OxLDL down-regulates eNOS and up-regulates iNOS, thereby augmenting the formation of NO and protein S-nitrosylation in human endothelial amyloid [26]. Importantly, iNOS-mediated S-nitrosylation plays an increasingly significant role in cardiovascular diseases [34]. For example, iNOS-mediated IRE1α
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br Protein protein interactions of
2019-08-27
Protein-protein interactions of LEI/L-DNase II and the control of cell death Evolutionary tips The serpin inhibitory mechanism is extremely well adapted to evolutionary changes because a single amino Protease Inhibitor Library substitution in the RSL can led to the inhibition of a totally dif
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br Prospect of DDR antagonist
2019-08-27
Prospect of DDR2 antagonist DDR2, a receptor of tyrosine kinase has been found now to be reported to play a significant role in onset of osteoarthritis at the early stage of diseases progression. The DDR2 are the receptor for extracellular collagen and activated upon the binding of collagen resul
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A factor that complicates the use of human liver cells
2019-08-27
A factor that complicates the use of human liver px express is one of variability, which arises in part because many of the human liver samples available for research show various stages of a variety of disease states (steatosis (fatty liver), cirrhosis, carcinogenesis in adjacent tissue), although
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It was thus found that E
2019-08-27
It was thus found that E1 plays an important role in G. intestinalis biology. Inhibiting E1 expression by RNA antisense in trophozoites was lethal while E1 overexpression induced a five-fold increase in cyst formation during encystation. The changes in E1 location during this process and its localiz
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River sand was graded in accordance with ASTM
2019-08-26
River sand was graded in accordance with ASTM C778 [47] (see Table 2). The graded sand had a water Punicalin kinase of 1.00%, fineness modulus of 3.49 and specific gravity of 2350kg/m3. A polycarboxylate based superplasticizer called ZP with pH of 7±1 and specific gravity of 1.1±0.02 was also used
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br Introduction Rhabdomyosarcoma RMS is a myogenic
2019-08-26
Introduction Rhabdomyosarcoma (RMS) is a myogenic tumor that accounts for approximately 50% of all pediatric soft tissue sarcomas. Diagnostic criteria for RMS SCF, murine recombinant protein on the validation of proteins of the skeletal muscle lineage, such as Desmin, MyoD or Myogenin [1]. RMS c
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A major open question in the
2019-08-26
A major open question in the field of lipid mediators is the molecular nature of the PLA2 enzyme involved in the release of DHA and related omega-3 fatty acids from phospholipids as a first committed step for the generation of SPMs. Although by analogy with AA it is often assumed that cPLA2α may ser
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