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There are two types of
2020-03-18
There are two types of DDRs, DDR1 and DDR2, which are type I transmembrane RTKs characterized by an N-terminal extracellular discoidin domain containing a collagen binding site [8]. DDR1 expression is somewhat restricted to epithelial cells, while DDR2 is often expressed in cells of mesenchymal orig
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Together the protein engineering approaches employed
2020-03-18
Together, the protein engineering approaches employed by Teyra et al., (2019) demonstrate the effectiveness of affinity maturation for improving the affinity of UbVs, but this comes at a cost in terms of specificity. Indeed, the most effective UbV was the dimeric construct generated from UbVs isolat
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Within the Class II receptors the Type I IFN
2020-03-17
Within the Class II receptors, the Type I IFN receptor subunit, IFNAR-1, is exceptional in having four tandem FNIII domains, denoted here D1–D4. This structure appears to have arisen as a tandem apexbt chemicals of the basic D1/D2 structure; thus, D1 and D3 of IFNAR-1 are more closely related, as a
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Regarding the effects of CRF on anxiety
2020-03-17
Regarding the effects of CRF on anxiety, Sahuque et al. (2006) have demonstrated that this neuropeptide also enhances anxiety when injected into the bed nucleus of the stria terminalis (BNST), a squalene epoxidase structure that has also been related to defensive behavior (Casada and Dafny, 1991, C
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In general up to date no study has considered
2020-03-17
In general, up to date, no study has considered thermodynamic modeling to estimate the Emodepside of SO2 by different DESs. Since experimental measurements are time consuming and expensive, general and accurate theoretical models are vital to estimate SO2 solubilities in different DESs over wide ra
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br Introduction br Multiple levels of CK AKT cross talk
2020-03-17
Introduction Multiple levels of CK2/AKT cross-talk Isoform-specific signaling in CK2/AKT cross-talk Particularly relevant to the scope of this review, it has been shown that depletion of the CK2 catalytic α′ subunit is more effective than that of the α subunit at reducing AKT Ser129 phospho
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br Chemistry A total of new ThDP
2020-03-17
Chemistry A total of 35 new ThDP analogs in the series of 7, 12, 15, and 19 were designed and synthesized (Scheme 1). The synthetic route is simple and convenient. In this synthetic route, 4-amino-2-methylpyrimidine-5-carbaldehyde 3 is a key intermediate for the synthesis of title compounds 7, 1
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SIRT has deacetylated regulation on numerous
2020-03-17
SIRT1 has deacetylated regulation on numerous nonhistone protein substrates [Atgs, Foxo1, Foxo3, PGC-1α, NF-kB, E2F1 and p53] (Conrad et al., 2016) to play a key role in protecting against cell stress. Therefore, the role of SIRT1 in fluorine-induced oxidative stress was explored. The results reveal
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br The contribution of Interference RNA
2020-03-17
The contribution of Interference RNA and epigenetic in OA attenuation Interference RNA, a cellular mechanism for post-transcriptional gene silencing that is associated with mRNA. The potential of RNAi has successfully silenced the wide range of protein coding genes. Its high specificity sanctions
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INCB028050 mg Exogenous administration of POCs could theoret
2020-03-16
Exogenous administration of POCs could theoretically inhibit breastfeeding [69]; however, the evidence in this review does not generally support a negative impact on breastfeeding outcomes. Studies examining the INCB028050 mg of POCs among postpartum women overall demonstrated no adverse effects on
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Of the acidic hydroxyazoles involved hydroxypyrazole had
2020-03-16
Of the acidic hydroxyazoles involved, hydroxypyrazole had the weakest acidic profile (pKa in the range of 6–7), although highly deprotonated at physiological pH. During hit optimization, the two pyrazole ring positions available for substitution provide an opportunity for a better exploration of the
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Tazobactam sodium salt With a favorable spectrum of
2020-03-16
With a favorable spectrum of CRTh2 dependent in vitro and in vivo efficacy demonstrated, the off-target activity of compound 18 was investigated, first against a panel of prostanoid receptors and related eicosanoid targets (Table 8), where no significant activities at 10μM concentration were found i
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ERR is constitutively active in the absence
2020-03-16
ERRγ is constitutively active in the absence of endogenous ligand. However, several synthetic ligands that can repress or induce ERRγ function by disrupting ERRγ-coactivator interactions have been reported to date. The estrogen receptor modulators diethylstilbestrol (DES) and 4-hydroxytamoxifen (4-O
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While agnathans appear to have reduced their Ednr
2020-03-16
While agnathans appear to have reduced their Ednr repertoire to the Ednra gene (that may have been amplified in the Arctic lamprey), gnathostomes in general have been relatively inert to Ednr gene loss. Strikingly, the only Ednr gene that has been lost repeatedly is EdnrB2 (lost in therian mammals,
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Despite robust translation of GA only small amounts of
2020-03-13
Despite robust translation of GA, only small amounts of GR and GP were translated in cultured rhein and chick embryo spinal cord neural cells from the 75 copies of G4C2 in monocistronic constructs. Interestingly, GA is also the most common dipeptide found in autopsy tissue in FALS patients with C9OR
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