• A correlation analysis was performed to

  2022-10-14

  

  A correlation analysis was performed to investigate a possible relationship between serum resistin levels and MG-ADL. We observed a significant relationship between serum resistin levels and MG-ADL scores in AChR-GMG-positive cases (r=0.285, p=0.032; Fig. 1C). There were also significant correlation

• br Introduction In myasthenia gravis

  2022-10-14

  

  Introduction In myasthenia gravis (MG), autoantibodies against the native AChR conformation cause loss of AChR at the neuromuscular junction and fatigable muscle weakness (Newsom-Davis et al., 1993). The AChR is a pentameric transmembrane protein, with two splice forms of the α-subunit, P3A− and

• br Acknowledgements br Introduction Resistant hypertension R

  2022-10-14

  

  Acknowledgements Introduction Resistant hypertension (RH), is defined as blood pressure (BP) > 140/90 mm Hg despite three full doses antihypertensive drugs including a diuretic. Controlled hypertensive patients taking four protease inhibitor cocktail or more of antihypertensives are also cons

• In this paper we describe the formation of a

  2022-10-14

  

  In this paper, we describe the formation of a structure-based pharmacophore which lead to the discovery of several hydrophobic, yet non-lipid inhibitors of ATX. These compounds docked within the same volume occupied by the initial non-lipid inhibitors of ATX used to build the pharmacophore. Violatio

• Infections inflammation and corneal transplant can all

  2022-10-13

  

  Infections, inflammation, and corneal transplant can all cause corneal neovascularization via upregulation of inflammatory cytokines, which attract myeloid Dexlansoprazole into the cornea. These myeloid cells establish a cycle of cytokine secretion and further myeloid cell recruitment in the cornea

• It is well known that TCDD is the most potent

  2022-10-13

  

  It is well-known that TCDD is the most potent ligand of AhR and it regulates gene expression, such as CYP1A1, via activation of AhR (Mimura and Fujii-Kuriyama, 2003). Besides Tomblin et al. (2016) have recently shown that TCDD via AhR regulated L-type amino Tacrolimus receptor transporter 1 express

• br Conflict of interest statement

  2022-10-13

  

  Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal (-)-p-Bromotetramisole Oxalate in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes within

• Some SNPs have been identified for HRH in

  2022-10-12

  

  Some SNPs have been identified for HRH in cancer (Table 4). Looking into breast cancer research, H4 receptor polymorphisms have been recently associated with the malignancy of the disease. This was evidenced upon the analysis of genotypes and haplotypes of a Chinese Han population; this study showed

• br STAR Methods br Acknowledgments We

  2022-10-12

  

  STAR★Methods Acknowledgments We thank Prof. Y. Tomari at the University of Tokyo for experimental advice and K. Hanada for technical assistance. This research was supported by Grants-in-Aid for Scientific Research on Innovative Areas “Nascent Chain Biology” (JP15H01548 and JP17H05677 to T.I. a

• Sulconazole Nitrate Introduction Hepatocellular carcinoma HC

  2022-10-12

  

  Introduction Hepatocellular carcinoma (HCC) is the fifth most lethal malignant tumor worldwide and is the second leading cause of cancer-related death [1]. For HCC patients, Sulconazole Nitrate virus (HBV) infection is the important causative risk factor in Asia-Pacific regions [[2], [3], [4]]. In

• The present results indicate that oxidative

  2022-10-12

  

  The present results indicate that oxidative damage in CFS muscles is not due to the decline in the efficiency of antioxidative enzymes. This suggests that there is an increase in the generation of reactive oxygen species consistent with a mitochondrial origin of the damage. Mitochondria represent th

• Agarose GPG/LMP low melt mg br Discussion In the present pap

  2022-10-12

  

  Discussion In the present paper it was shown for the first time that the conjugation of ethacrynic Agarose GPG/LMP low melt mg and glutathione catalyzed by GSTP1-1 stereospecifically forms one of the diastereoisomers of the glutathione conjugate (EASG). Chemical conjugation results in formation

• br GSNOR regulates SA synthesis and SA signalling The

  2022-10-12

  

  GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic Alfacalcidol (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal resistan

• br Lysophosphatidylinositol LPI LPI is a

  2022-10-12

  

  Lysophosphatidylinositol (LPI) LPI is a subspecies of lysophospholipid consisting of inositol as its head group, one glycerol molecule and one acyl chain (Piñeiro and Falasca, 2012). The biosynthesis of this lipid starts from Phosphatidylinositol (PI) and is catalysed by the enzymes phospholipase

• In the brain hydrolysis of AG

  2022-10-12

  

  In the brain, hydrolysis of 2-AG by MGL is the primary source of AA for conversion to PGs by cyclooxygenase (Nomura et al., 2011). PGE2 production is required for IL-1β-evoked synapse loss (Mishra et al., 2012). Here, we tested whether decreased PG levels contributed to the synapse protective effect

15583 records 359/1039 page Previous Next First page 上5页 356357358359360 下5页 Last page