• br Acknowledgments This review is based in

  2022-02-21

  

  Acknowledgments This review is based in part on research conducted with financial support from the General Research Fund (17112914) of the Hong Kong Research Grant Council and from the Seed Funding Programme for Basic Research by University Research Committee of the University of Hong Kong (20151

• Others demonstrated that Paneth cells

  2022-02-21

  

  Others demonstrated that Paneth cells maintain stem cell function and crypt homeostasis by providing metabolic lactate to sustain the enhanced mitochondrial oxidative phosphorylation in the Lgr5+ ISCs (Rodriguez-Colman et al., 2017), which substantially agrees with our findings in this study. Furthe

• Continuing studies of endocannabinoid ligands at

  2022-02-21

  

  Continuing studies of endocannabinoid ligands at GPR55 reveal that virodhamine (O-arachidonylethanolamine) and AEA can act as a partial agonists at GPR55; at high micromolar concentrations can inhibit β-arrestin recruitment (Sharir et al., 2012). It is likely that there are allosteric as well as ort

• β-Sitosterol mg In three independent groups identified GPR

  2022-02-21

  

  In 2003, three independent groups identified GPR109A (HM74A) and GPR109B (HM74), two GPCRs, as the receptors for niacin., , GPR109A, which is present in all species, is a high affinity receptor for niacin., GPR109B, which is only present in human and chimpanzee, is a low affinity receptor for niacin

• To facilitate the development of novel diagnostic and therap

  2022-02-21

  

  To facilitate the development of novel diagnostic and therapeutic interventions in NASH, a plethora of animal models have been used to identify molecular targets that are involved in the onset and progression of NASH. In view of recent advances in the understanding of the pathogenesis of NASH and pr

• We also observed a significantly higher SLC A gene

  2022-02-18

  

  We also observed a significantly higher SLC10A1 gene expression and NTCP protein level among metastatic individuals vs. donor livers. Na+/taurocholate co-transporting polypeptide (NTCP), which is expressed on the basolateral membrane of hepatocytes and is primarily responsible for the uptake of bile

• br Methods and materials br Results

  2022-02-18

  

  Methods and materials Results To examine the fear conditioning effects of the pre-exposure, drug, and sex factors in the total latency time, a 2 × 3 × 2 three-way ANOVA indicated that find more information significant differences occurred in the drug (F2109 = 14.44, p 0.05) and pre-exposure

• pHi regulation in astrocytes has been examined

  2022-02-18

  

  pHi regulation in astrocytes has been examined primarily in cell culture rather than in situ. Two HCO3−-dependent transporters, NBC and Na+-driven Cl-HCO3 exchange (NDCBE), have been described [10,16], in addition to Cl-HCO3 anion exchange (AE) [96]. Culture studies indicate that NHE is the principa

• Given the proposed importance of conformational dynamics to

  2022-02-18

  

  Given the proposed importance of conformational dynamics to GCK's allosteric regulation, a number of biophysical methods have been utilized to probe the enzyme's dynamic structural landscape. Investigations into the mechanism of GSK1904529A binding, using changes in the enzyme's intrinsic fluoresce

• Piezo channels can be activated by many mechanical

  2022-02-18

  

  Piezo channels can be activated by many mechanical stimuli . While some of these stimulations directly mimic physiological forces experienced by Melittin , such as shear stress applied in a microfluidic chamber, the most commonly used modes of stimulation consist of stretching the membrane by appl

• Cx is the major molecule involved in

  2022-02-18

  

  Cx43 is the major molecule involved in the dynamic life cycle of GJIC (Cusato et al., 2006). Initially generated Cx43 exist in the cytoplasm and correctly transfer it to the plasma membrane during its life cycle (Ji et al., 2018). To understand the toxic effects of MC-LR on GJIC, Cx43 localization w

• DNAzymes a series of nucleotide sequences with

  2022-02-18

  

  DNAzymes, a series of nucleotide sequences with specific catalytic activity, have been reported frequently applied in detection assays for such as ions and amino acids, due to the advantage in stability, high cost-effectiveness and modification convenience, by comparison with protein enzymes. The DN

• In the upper part of the intestine a small amount

  2022-02-18

  

  In the upper part of the intestine a small amount of conjugated BAs are reabsorbed via passive diffusion, whereas the part of BAs that escape enterohepatic circulation passes into the colon where they undergo bacterial conversions such as deconjugation, dehydroxylation or dehydrogenation, into secon

• The regulatory effects of NADPH oxidase on ferroptosis might

  2022-02-18

  

  The regulatory effects of NADPH oxidase on ferroptosis might also relate to neuroinflammation. Although ferroptosis can trigger inflammatory responses in the brain, neuroinflammation, in turn, can also modify ferroptosis. It has been reported that inflammatory conditions such as those found in neur

• The current lack of effective treatments for

  2022-02-18

  

  The current lack of effective treatments for primary or metastatic UM leaves a large therapeutic gap for patients and clinicians underscoring an urgent need for the identification of additional pharmacological targets for therapeutic intervention. As YAP-targeting strategies have remained elusive th

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