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br Materials and methods br Results br
2019-07-02
Materials and methods Results Discussion The main finding of the present study is that selective ETA and dual ETA/ETB receptor blockade markedly improve endothelium-dependent vasodilatation in patients with type 2 diabetes and vascular complications. The magnitude of improvement did not dif
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Tibolone is also efficacious on bone in elderly women
2019-07-02
Tibolone is also efficacious on bone in elderly women and induces a clear reduction in bone turnover markers [50], [51]. Rymer et al. showed that, after 10 years of treatment with tibolone, the difference in bone mineral density compared with a placebo group was more than 12% for both lumbar spine a
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The use of the periplasmic fraction as
2019-07-02
The use of the periplasmic fraction as starting material and the presence of a unique purification step concurred in improving the purification yield to 25.3%, which is significantly higher than what obtained with the previous purification protocol (6.7%). In addition, the analysis of the kinetic co
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Importantly our in vivo data fit to the in vitro
2019-07-02
Importantly, our in vivo data fit to the in vitro data, further confirming the synergistic effect of XJD and gefitinib on the inhibition of lung cancer and the regulation of SP1, HOTAIR, and EP4 Sodium Aescinate levels. The doses of XJD used were based on our previous in vivo study (Zhao et al., 20
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br Enzyme activations Activated proteinases
2019-07-02
Enzyme activations Activated proteinases can unleash a deluge of tissue damage (Zucker et al., 2009). Once activated, the essential enzymes such as serine proteases and cysteine proteases cannot discriminate between self and non-self, burning away self-tissues (Chien et al., 2009, Laskar et al.,
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br Conclusions Mulan is a mitochondrial E ubiquitin ligase w
2019-07-02
Conclusions Mulan is a mitochondrial E3 ubiquitin ligase with diverse roles in cell growth, cell death, and mitophagy. To better understand the mechanism of Mulan\'s function we used a modified yeast two-hybrid system to isolate proteins that interact with its cytoplasmic RING domain (amino acids
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In Fatima Mir and colleagues report results from
2019-07-01
In , Fatima Mir and colleagues report results from the Simplified Antibiotic Therapy Trial (SATT) in Pakistan, in which three antibiotic regimens were compared for treatment of neonatal infections: procaine benzylpenicillin and gentamicin; amoxicillin and gentamicin; and procaine benzylpenicillin, g
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Conflict of interest br Introduction Nifekalant hydrochlorid
2019-07-01
Conflict of interest Introduction Nifekalant hydrochloride was first approved by the Japanese Ministry of Health, Labour and Welfare in 1999 and is now used as a first-line antiarrhythmic drug for refractory ventricular tachyarrhythmias in the country [1]. Nifekalant is a class III antiarrhythmi
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br Recalls and advisories Managing components under
2019-07-01
Recalls and advisories Managing components under advisory notices poses several daunting challenges. Fig. 5 illustrates the benefit of HM for the management of recalled components [29,32]. Advisories encompass disintegration of high-voltage circuitry, battery depletion, and lead failure—almost al
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br Genetic basis Similar to
2019-07-01
Genetic basis Similar to other arrhythmia syndromes, Brugada and early repolarization syndromes are inherited diseases that are usually transmitted in an autosomal-dominant manner [26]. To date, 13 genes have been associated with Brugada syndrome. Loss-of-function mutations in SCN5A, encoding the
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Another recent study also concluded that presence of
2019-07-01
Another recent study also concluded that presence of EMD at diagnosis, rather than any treatment modalities ever used, was the only significant predictor of extramedullary recurrence. This finding suggests that the development of EMD, even during treatment, may possibly reflect different tumor biolo
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In this study we applied a more general
2019-07-01
In this study, we applied a more general approach along these lines, which has previously been used only in few reports in the literature [8]. Based on a prospective BC database including all newly diagnosed BC cases at a large Swiss breast center over a 20-year period, we aimed to give a comprehens
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De hecho la desordenada colecci
2019-07-01
De hecho, la desordenada colección de los datos etnográficos se encuentra varias veces en conflicto con la propuesta de un proyecto sistemático que el fraile busca plantear, sin éxito, en el exordio de su obra. En las primeras páginas de la Relación, Pané esboza los confines de un modelo hermenéutic
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Case report A year old Caucasian
2019-07-01
Case report A 76 year-old Caucasian male who was evaluated in an emergency department due to headache in May 2001 and was found to have a right parietal subdural hematoma (SDH). Baseline blood work revealed thrombocytopenia of 50×109/L. His SDH was managed with surgical evacuation with full recover
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br Discussion Pocket hematoma is a frequent complication in
2019-06-29
Discussion Pocket hematoma is a frequent complication in the early stages following cardiac device side effects and its incidence has been reported to be 0.9–22% [11–16,18–22]. In this study, 161 patients underwent cardiac device surgery and 10 (6.2%) of these patients had bleeding complications
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