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The ESC update emphasizes the need for
2020-03-06
The 2017 ESC update emphasizes the need for implementing strategies to minimize PCI-related complications, including risk stratification for ischemia and bleeding, keeping triple antithrombotic therapy to the shortest possible duration with dual antithrombotic therapy as an alternative, using non–vi
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Apart from the ET system s role in
2020-03-05
Apart from the ET system\'s role in regulating blood vessel tone, it is also involved in a variety of cellular processes that are relevant to DR. For example, the ET receptors influence the survival of retinal ganglion Madecassic acid (McGrady et al., 2017; Tonari et al., 2012), development of the
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One step in pyrimidine biosynthesis is conversion of l dihyd
2020-03-05
One step in pyrimidine biosynthesis is conversion of l-dihydroorotate (DHO) to orotate (ORO), under action of the enzyme dihydroorotate dehydrogenase (DHODH, EC 1.3.99.11), which contains a flavine (FMN) as redox cofactor [1]. In this transformation, electrons resulting from DHO oxidation are transf
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Besides by substrate and product KSTDs
2020-03-05
Besides by substrate and product, Δ1-KSTDs may also be inhibited by other steroids. N. simplex ATCC 6946 Δ1-KSTD was strongly inhibited non-competitively by dicortinone (60), a steroidal dimer, and by bis-1-dehydrodicortinone, with values of 0.7 and 0.75 μM, respectively. This enzyme was also inhib
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Global inhibition of integrin signaling with
2020-03-05
Global inhibition of integrin signaling with EDTA here suggests that integrin signaling potentially cooperates with DDR2 in collagen induction of lysyl oxidase. This notion is supported by a recent study that shows DDR2 cooperation with specific integrins in cell adhesion to collagen [47]. It is of
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br DDR role in kidney
2020-03-05
DDR1 role in kidney Thirty-eight papers are reported in PubMed upon the keyword search “DDR1 AND kidney”. Careful examination of those papers shows that only 31 are related to DDR1\'s role in glomerulosclerosis and renal fibrosis, 24 of those being research and the rest review articles. Since the
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Proteolysis by CPs is crucially important for cereal seed
2020-03-05
Proteolysis by CPs is crucially important for cereal seed development and germination. However, these enzymes must be tightly controlled. Pre-harvest sprouting is a phenomenon in which the control of CPs is disrupted. This disruption manifests in the premature synthesis and activation of CPs, leadin
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br Materials and methods br
2020-03-05
Materials and methods Results Discussion CHIKV is an important arthropod borne virus with substantial impact on global health and cause a major viral disease that requires the development of antiviral drug to combat chikungunya disease. Virus specific proteases have particularly become an a
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Furthermore down regulation of Cpt a
2020-03-05
Furthermore, down-regulation of Cpt1a, ApoE, Fasn, Pxr, and Srebp-1 genes indicates a down-regulation of lipid metabolism associated genes while Fatp1 is up-regulated and indicates an increase in fatty telomerase inhibitor transport genes involved in accumulation [84,85]. These changes in gene expr
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The interest for lanthanide and
2020-03-05
The interest for lanthanide and actinide complexes appeared again recently, due to their unique features in the design of Single Molecule Magnets (SMM). Lanthanide SMMs are interesting due to large their intrinsic magnetic anisotropy, but their core 4f orbitals minimally participate in exchange inte
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Rosiglitazone maleate The associations between genetic facto
2020-03-05
The associations between genetic factors and socio-emotional functioning are complex and almost certainly not direct. They are mediated through a variety of developmental processes including individual differences in personality traits (Davis and Loxton, 2013, Saphire-Bernstein et al., 2011). For th
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Potential break through technology poised to
2020-03-05
Potential break-through technology poised to overcome these above-mentioned limitations is that of the “substrate mediated enzyme prodrug therapy”, SMEPT (Fig. 1). Learning from the previously established enzyme prodrug therapies (EPT) and specifically the antibody-directed EPT (ADEPT) [12], develop
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Our research has demonstrated that the absolute bioavailabil
2020-03-05
Our research has demonstrated that the absolute bioavailability of oxymatrine, having a similar structure with OSC, was only 6.79±2.52%. About 50% of OSC was converted to its active metabolite SC in vivo; hence, the absolute bioavailability of OSC was speculated to be poor as well [24]. Understandi
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Although the reasons why viral RNA does not bind to
2020-03-05
Although the reasons why viral RNA does not bind to and activate PKR in WNV-infected cells are not known, some of the known characteristics of flavivirus infections provide possible clues. The viral PD 169316 protein forms dimers that associate with ER membranes and viral RNA (Lindenbach et al., 200
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Progesterone s metabolite THP may also
2020-03-05
Progesterone\'s metabolite, 3α,5α-THP, may also be mediating burying and freezing responses. Results show female Long–Evans rats in behavioral estrous have higher P4 levels in serum, Ac-IETD-AFC mg and hippocampus compared to diestrous female Long–Evans rats. Additionally, ovx female Long–Evans rat
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