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br The recommendation process The recommendation process con
2020-08-04
The recommendation process The recommendation process consists of four phases as illustrated in Fig. 7, namely query expansion, COTS components repository filtering, COTS components retrieval, and results ranking and display. The user triggers the process by submitting a query composed of a set o
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br Introduction Protein kinase CK is a serine threonine prot
2020-08-04
Introduction Protein kinase CK2 is a serine/threonine protein kinase responsible for the phosphorylation of more than 300 physiological substrates, and plays important roles in Trimidox progression and multiple signal transduction pathways [1,2]. Increasing evidence suggests that deregulation of
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With the present approach it was
2020-08-04
With the present approach, it was possible to ascertain that uranium by itself, and under realistic conditions, was not able to induce anticholinergic neurotoxicity on the animal models C. fluminea, D. magna, and C. auratus. If no effects were observed after exposure and following recovery periods,
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The hemiketal complex formed by acetophenones with cholinest
2020-08-04
The hemiketal complex formed by acetophenones with cholinesterases is analogous to the tetrahedral transition state intermediate formed during the hydrolysis of ester substrates like acetylcholine, and enzyme stabilization of this complex promotes catalytic hydrolysis. Since all the acetophenone com
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br Materials and methods br Results
2020-08-04
Materials and methods Results Discussion The membrane PVase activity components were discriminated in this work by pre-incubating with PMSF, mipafox, paraoxon or PMSF + mipafox to irreversibly inhibitPVase activity to discriminate the enzymatic components, (EPα, EPβ, EPγ and EPδ). The conce
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Although CYP E is also suspected of
2020-08-04
Although CYP2E1 is also suspected of being the major catalyst of CCl4 reduction in humans [7], the role of the various human CYP450 forms in CCl4 metabolism over a range of CCl4 concentrations has not been established. An understanding of which CYP450 forms contribute to CCl4 metabolism would provid
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Although Bach is expressed in diverse cell
2020-08-04
Although Bach1 is expressed in diverse cell types, no clear defects are observed in Bach1-deficient mice under normal conditions [10]. Bach1-deficient mice also exhibit elevated disease tolerance in various models, including atherosclerosis in ApoE double-knockout mice [38], lung damage after high o
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Some E s have been
2020-08-04
Some E2s have been shown to bind to co-factors that can alter the activity or subcellular localization of the recruited E2 [28]. One example is the CUE1 co-factor which recruits the cytoplasmic UBC7 (UBE2G2) E2 enzyme to the endoplasmic reticulum (ER) where it participates in the degradation of misf
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The Egr gene is one of the
2020-08-04
The Egr1 gene is one of the early response genes dramatically and rapidly induced upon stimulation with many environmental signals including growth factors, hormones, and neurotransmitters (Gupta et al., 1991, Kaufmann et al., 2001, Liu et al., 2005, Sato et al., 1999). Egr1 functions as a convergen
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br Thermodynamic modeling br Selection of data The solutes w
2020-08-03
Thermodynamic modeling Selection of data The solutes were selected based on the set of data needed to evaluate the CPA-EoS for prediction of their solubility in CO2 + cosolvent, as shown in Fig. 1. Critical temperatures, melting temperatures and enthalpies of fusion of the solutes are required
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br Materials and methods br Results and
2020-08-03
Materials and methods Results and discussion Concluding remarks The successful knockout of the tpi1 gene in K. pneumoniae DSM2026 and the physiological study of mutants grown on different carbon sources led to the discovery of a novel tpi2 gene in this bacterium. The direct enzyme assay and
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Working under the hypothesis that differences in COMT are as
2020-08-03
Working under the hypothesis that differences in COMT are associated with aberrant ethanol seeking and intake, the current project sought to investigate the influence of alterations in COMT activity and expression on alcohol seeking and drinking. While sex-linked differences in COMT protein expressi
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Also our data from this study
2020-08-03
Also, our data from this study indicate that gestational GC exposure altered hematological and hemorheological parameters, however reports exist that altered blood rheological markers are associated with atherosclerosis and CVD (Tzoulaki et al., 2007). Also, the platelet to lymphocyte ratio (PLR) ha
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Nevertheless we observed that isolated carp leukocytes stimu
2020-08-03
Nevertheless, we observed that isolated carp leukocytes stimulated with bacteria are sensitive to natural and synthetic glucocorticoids, which have already been reported to be immunosuppressive. Accordingly, it was noted that compared to control measurements the glucocorticoids PF-562271 (F), corti
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br Conclusions br Acknowledgments This work was supported
2020-08-03
Conclusions Acknowledgments This work was supported by the National Natural Science Foundation of China (grant number: 81273109). Introduction Renal cell carcinoma (RCC) is the second leading urogenital malignancy in China, accounting for 2%–3% of all adult cancers. Although an increasing
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