• VER 155008: Modulating Hsp70 Activity in Proteinopathy an...

  2025-09-23

  This article explores the mechanistic role of VER 155008, a potent HSP 70 inhibitor, in modulating chaperone-regulated phase separation and apoptosis signaling, with implications for both cancer research and neurodegenerative disease models.

• TNF-alpha Recombinant Murine Protein: Dissecting Apoptoti...

  2025-09-22

  Explore how TNF-alpha recombinant murine protein advances apoptosis and inflammation research by enabling mechanistic studies of cell death beyond transcriptional shutdown, as highlighted by recent discoveries in mitochondrial signaling. This article offers practical guidance for leveraging recombinant TNF-alpha expressed in E. coli in cutting-edge cell culture experiments.

• FLAG tag Peptide (DYKDDDDK): Precision in Recombinant Pro...

  2025-09-19

  Explore the utility of FLAG tag Peptide (DYKDDDDK) as a versatile epitope tag for recombinant protein purification, detection, and functional mechanistic assays. This article highlights technical considerations, solubility properties, and novel research applications, providing actionable guidance for protein scientists.

• EZ Cap Cy5 Firefly Luciferase mRNA: Innovations in Modifi...

  2025-09-18

  Explore how EZ Cap Cy5 Firefly Luciferase mRNA (5-moUTP) advances mammalian expression studies and mRNA delivery strategies through enhanced stability, translation efficiency, and fluorescence tracking. This article highlights the unique properties of 5-moUTP modified mRNA and its applications in translation efficiency assays and in vivo bioluminescence imaging.

• glutamate receptor agonist br Materials and Methods br Resul

  2025-03-03

  

  Materials and Methods Results A total of 28 NSCLC tumor samples from 26 patients (2 patients with paired tumor samples) were included. According to the initial FISH (Abbott Molecular probes) and IHC results, 13 samples were ALK IHC+FISH+, 5 samples were ALK IHC+FISH−, 2 samples (from the same

• br Endocytosis of AdipoR Surface

  2025-03-03

  

  Endocytosis of AdipoR1 Surface receptor activity may be shut down by endocytic uptake and subsequent lysosomal degradation of the proteins [20]. Clathrin-dependent endocytosis (CDE) has been extensively studied and internalization from the plasma membrane is mediated through clathrin-coated pits

• hiv protease inhibitor br Adiponectin receptors in colorecta

  2025-03-03

  

  Adiponectin receptors in colorectal cancer development APN receptors expressed in CRC tissue may mediate its effects on cell expansion and cell death (Byeon et al., 2010). It was observed that the expression of AdipoR1 and 2 is higher in CRC tissue than in counterpart healthy tissues (Williams et

• br Introduction Nausea and vomiting are among the most

  2025-03-03

  

  Introduction Nausea and vomiting are among the most distressing side effects associated with chemotherapy in cancer patients (Billio et al., 2010). Severe emesis can negatively affect a patient's nutritional state, ability to work and motivation, which can, in turn, interfere with the clinical co

• br Actin at presynapses br Conclusion

  2025-03-03

  

  Actin at presynapses Conclusion Thanks to the recent discovery of rings, hotspots and trails, axonal chembridge is back in the spotlight. These are exiting times for neuronal cell biologists armed with constantly improving labeling and imaging techniques to observe, quantify and perturb these

• br Dihydrotestosterone in adult fish and

  2025-03-03

  

  Dihydrotestosterone in adult fish and frogs New perspectives and next directions Similar to other androgens, DHT can modulate reproductive endpoints in both fish and amphibians. However, predicting the effects of DHT can be challenging, as reproductive homeostasis is dependent upon the balance

• Anti LT therapy by LO inhibition has been hampered by

  2025-03-03

  

  Anti-LT therapy by 5-LO inhibition has been hampered by occurring liver toxicities by Zileuton or the clinical phase II compound Atreleuton [36], [37] However both compounds possess a thiophene as well as an N-hydroxyurea moiety. These features could be linked with reactive thiophene intermediates [

• br Introduction The principal pathways

  2025-03-03

  

  Introduction The principal pathways of adrenal and gonadal steroidogenesis have been known for over 50 years (reviewed by Miller and Auchus, 2011). Cholesterol is first converted to pregnenolone via three reactions, 20-hydroxylation, 22-hydroxylation and scission of the 20,22 carbon–carbon bond,

• br Materials and methods br Results br

  2025-03-03

  

  Materials and methods Results Discussion Author contributions JH purified protein, performed vanadate inhibition experiments, crystallized, collected data, determined and refined the ATX-VO5 structure, analysed all the structures, prepared the displayed items and supervised ALHE; WJK con

• br Application of bamboo in the food and

  2025-03-01

  

  Application of bamboo in the food and pharmaceutical industry For decades, the application of antioxidants in the food and pharmaceutical industry has been widespread. In the past, antioxidants were previously used to control oxidation and retard spoilage but today, many are used because of putat

• APP is a member of a conserved protein family

  2025-03-01

  

  APP is a member of a conserved protein family that also includes amyloid precursor-like proteins 1 and 2 (APLP1, APLP2).8, 9, 10 The proteins in this family are type I single-pass transmembrane Anticancer therapy with receptor-like structural features but not entirely clear cellular functions.11, 12

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